My understanding, from quite a long time ago, is that founts Georgia and Verdana were designed specifically to display best on screens – others are mainly meant for high-resolution paper printing. Lucida Console is another fount designed for screens. I don’t know if this information is still valid.
Another eyesight assistance if working in poor light is a backlit keyboard. Not a fancy multicoloured one for snazzy games, just a white light underneath the keys. If on battery, switch the backlight off unless needed.